The SMART Health Track sessions are organized to highlight cutting-edge research efforts in contemporary fields of Neuroscience and Cancer. The presentations will be centered around compelling topics such as molecular/neural mechanisms for neurodevelopment, synaptic plasticity and animal behavior as well as cancer genomics, cell migration in in vivo-like 3D environment and DNA repair. These Health Track sessions may provide an opportunity for a glimpse of specific, measurable, achievable, relevant and time-oriented endeavor to unveil some of the fundamental mechanisms of brain function and cancer progression, and their translational potential for clinical and public health applications.
|August 15 Thursday, 11:00 AM – 12:30 PM at Grand Ballroom H|
|Chair: Kyungjae Myung (UNIST)|
|11:00 AM||[Health Track Keynote] Neural circuits underlying the ‘Eye Movement Desensitization and Reprocessing’, a psychotherapeutic regimen for fear disorders
Hee-sup Shin (University of Chicago)
|11:30 AM||[Health Track Keynote] Harnessing plasticity in the visual cortex to promote amblyopia recovery
Elizabeth Quinlan (University of Maryland)
|12:00 PM||[Health Track Keynote] GPCR signaling in neurodevelopment and neuroprotection
Hee-Yong Kim (National Institute of Health)
|August 16 Friday, 11:00 AM – 12:30 PM at Grand Ballroom H|
|Session: Soft and Living Matter|
|Chair: Hee-Yong Kim (National Institute of Health)|
|11:00 AM||[Health Track Plenary] Visualizing molecular, cell, and tissue dynamics in 3D
Kenneth Yamada (National Institute of Health)
|11:30 AM||[Health Track Plenary] Mutational signatures in cancer and their application to the clinic
Peter J. Park (Harvard University Medical School)
|12:00 PM||[Health Track Plenary] Translating DNA repair for cancer therapy
Kyungjae Myung (Institute for Basic Scienc and Ulsan National Institute of Science and Technology)
Chair and Co-Chair
|Health Track Chair
National Institute of Health
|Health Track Co-Chair
Smart Health Keynote Speakers
Dr. Hee-sup Shin, Director, Center for Cognition and Sociality Institute for Basic Science (IBS)
Since mid-90’s Dr. Hee-Sup Shin’s group has pioneered in applying molecular genetics to studying neural mechanisms for animal behaviors, primarily focusing on defining the role of the thalamus. His approach to this objective was by elucidating the physiological consequences of deranged regulation of intracellular Ca2+ level in neuronal cells, because proper regulation of the cytoplasmic Ca2+ level is critical for neuronal functions. He utilizes a wide range of techniques, including molecular genetics, physiology in vivo and in vitro, optogenetics, and behaviors. Beginning in 2010 his group’s research focus has been evolved to studying the neurobiology of social behaviors. Shin’s group has pioneered in developing a behavioral assay called observational fear learning, a new behavioral paradigm for studying empathy fear in the mouse. Using this system they revealed that the circuits involving the thalamus, the anterior cingulate cortex and the amygdala control the empathy fear behavior.
Dr. Elizabeth Quinlan, Professor, Neuroscience and Cognitive Science Program, Univ. Maryland
Elizabeth Quinlan is a neuroscientist that studies the impact of age and experience on the function of cortical circuits. She received a Ph.D. in Biology/Neuroscience from the University of Illinois at Chicago and Postdoctoral training in Neuroscience at the University of Virginia and Brown University. She joined the faculty of the Department of Biology at University of Maryland in 2001, where she is currently a Professor. She is the scientific co-director of two major campus neuroscience initiatives: the Brain Health and Human Performance Initiative, which supports collaboration between the UM College Park, and the UM College of Medicine; and the Brain and Behavior Institute, which fosters collaboration between life sciences, physical sciences and engineering. She is one of the founding members of the Physiological Systems graduate program at UM, and is an associate editor at the journal Visual Neuroscience. Her lab has pioneered the use of sensory deprivation to promote plasticity and “rejuvenate” circuits in the adult cortex to promote recover function lost by disuse or injury. This work was recognized with The Advancement of Science Award, from the Neuro-Optometric Rehabilitation Association.
Dr. Hee-Yong Kim, Senior Investigator and Laboratory Chief, NIH
Dr. Hee-Yong Kim studies lipid biochemistry and cell membrane-related molecular signaling mechanisms underlying neurodevelopment and neuroprotection. She graduated from Seoul National University in South Korea and received her Ph.D. in Chemistry from University of Houston with specialization in mass spectrometry. Dr. Kim joined NIH and was subsequently tenured in 1992 and served as a Section Chief at the Intramural Research Program of National Institute of Alcohol Abuse and Alcoholism until she became the Chief of Laboratory of Molecular Signaling in 2006. Dr. Kim’s laboratory discovered lipid-derived novel endogenous molecular mechanisms for optimal development and protection of the brain. Her multidisciplinary research team developed mass spectrometry-based lipidomic, metabolomic and quantitative proteomic approaches to reveal protein-lipid/protein-protein interactions and conformational changes of proteins including GPCRs. Her current investigation is focused on the translation of these fundamental mechanisms to in vivo neuroprotective and therapeutic potential in brain injury models.
Dr. Kenneth Yamada, Distinguished Investigator, National Institutes of Health (NIH)
Dr. Kenneth Yamada’s research focuses on the dynamic interactions and movements of cells and their surrounding 3D extracellular matrix as tissues are remodeled in real time. His group identifies novel mechanisms and regulators of cell interactions and their roles in tissue remodeling during embryonic development and cancer cell invasion. He received BA, MD, and PhD degrees from Stanford University, and was a Section Chief at the National Cancer Institute for 10 years and a Section Chief at NIDCR, NIH since 1990 – currently heading the Cell Biology Section. Elected a Fellow of the AAAS in 1991, he received the first Senior Investigator Award of the American Society for Matrix Biology in 2004, Distinguished Scientist Award of the American Association for Dental Research in 2008, promotion to NIH Distinguished Investigator in 2011, and was elected as a Fellow of the American Society for Cell Biology (ASCB) in 2017.
Dr. Peter J Park, Professor, Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics Ph.D. program.
Dr. Park’s research specializes in computational and statistical analysis of high-throughput sequencing data in epigenomics and cancer genomics. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His group has developed several algorithms used around the world for analyzing structural alterations in cancer genomes as well as chromatin modifications. He is a co-leader of the Cancer Data Sciences Program at Harvard/Dana-Farber Cancer Center and a member of the Division of Genetics at Brigham and Women’s Hospital and the Harvard Stem Cell Institute.
Dr. Kyungjae Myung, Director Center for Genomic Integrity (CGI), Institute for Basic Science (IBS); Distinguished Professor, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)
Professor Myung is the director of the Center for Genomic Integrity, established in December 2014. In 1991 he received his B.S. in Zoology and then in 1993 earned his M.S. in Molecular Biology, both from Seoul National University. He completed his Ph.D. in Molecular Biology, Cell Biology and Biochemistry at Brown University in 1999. He started his independent research career at the National Human Genome Research Institute (NHGRI) in 2002 and promoted as a senior Investigator. In 2014, he returned to Korea and took up his position at IBS. Dr. Myung’s research interest has been focused on genomic integrity, which are challenged by endogenous and exogenous asserts such as replication errors or oxidation stresses and radiation or toxic chemicals, respectively. He has been studying multiple DNA repair pathways at the molecular level using small molecules with molecular, cell biological and biochemical techniques and animal models.